Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma.

ABSTRACT:

Backgrounds

Kidney renal clear cell carcinoma (KIRC) is a major pathological type of renal cell carcinoma (RCC), and the prognosis of advanced KIRC patients is often unsatisfactory. Some lysine oxidase (LOX) family genes have been proven to be upregulated in some malignancies and play pivotal roles in the carcinogenesis. However, their roles in KIRC remain unclear.

Materials and methods

Here, we used some online databases (eg, ONCOMINE, GEPIA, UALCAN, c-BioPortal, Human Protein Altas) to comprehensively explored the expression levels and the prognostic values of LOX family genes in KIRC using bioinformatic methods.

Results

The results revealed that lysyl oxidase (LOX) and lysyl oxidase-like 2 (LOXL2) were significantly overexpressed in KIRC at the level of mRNA expres

SUBMITTER: Lin S 

PROVIDER: S-EPMC7666732 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature