A risk stratification model for predicting brain metastasis and brain screening benefit in patients with metastatic triple-negative breast cancer.

ABSTRACT:

Background

Patients with metastatic triple-negative breast cancer (mTNBC) frequently experience brain metastasis. This study aimed to identify prognostic factors and construct a nomogram for predicting brain metastasis possibility and brain screening benefit in mTNBC patients.

Methods

Patients with mTNBC treated at our institution between January 2011 and December 2018 were retrospectively analyzed. Fine and Gray's competing risks model was used to identify independent prognostic factors. By integrating these prognostic factors, a competing risk nomogram and risk stratification model were developed and evaluated with concordance index (C-index) and calibration curves.

Results

A total of 472 patients were retrospectively analyzed, including 305 patients in the training

SUBMITTER: Lin M 

PROVIDER: S-EPMC7666757 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature