Epidural Oscillating Cardiac-Gated Intracranial Implant Modulates Cerebral Blood Flow.

ABSTRACT:

Background

We have previously reported a method and device capable of manipulating ICP pulsatility while minimally effecting mean ICP.

Objective

To test the hypothesis that different modulations of the intracranial pressure (ICP) pulse waveform will have a differential effect on cerebral blood flow (CBF).

Methods

Using an epidural balloon catheter attached to a cardiac-gated oscillating pump, 13 canine subjects underwent ICP waveform manipulation comparing different sequences of oscillation in successive animals. The epidural balloon was implanted unilaterally superior to the Sylvian sulcus. Subjects underwent ICP pulse augmentation, reduction and inversion protocols, directly comparing time segments of system activation and deactivation. ICP and CBF were measured bil

SUBMITTER: Luciano MG 

PROVIDER: S-EPMC7666905 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature