The genetic basis for the inverse relationship between rheumatoid arthritis and schizophrenia.

ABSTRACT:

Introduction

Rheumatoid arthritis is a common autoimmune disease and schizophrenia is a relatively common and debilitating neurological disorder. There are several common features between rheumatoid arthritis and schizophrenia. The inverse relationship between rheumatoid arthritis and schizophrenia has been replicated in several studies. Despite evidence for an inverse epidemiological relationship and negative correlations for risk between rheumatoid arthritis and schizophrenia, there are no biological data that directly support this inverse relationship.

Materials and methods'

We meta-analyzed the genome-wide association studies to investigate the shared association loci between rheumatoid arthritis and schizophrenia at the genome-wide scale. Rheumatoid arthritis- and schiz

SUBMITTER: Zamanpoor M 

PROVIDER: S-EPMC7667353 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature