Altered long- and short-range functional connectivity density associated with poor sleep quality in patients with chronic insomnia disorder: A resting-state fMRI study.

ABSTRACT:

Introduction

Previous neuroimaging studies have suggested that brain functional impairment and hyperarousal occur during the daytime among patients with chronic insomnia disorder (CID); however, alterations to the brain's intrinsic functional architecture and their association with sleep quality have not yet been documented.

Methods

In this study, our aim was to investigate the insomnia-related alterations to the intrinsic connectome in patients with CID (n = 27) at resting state, with a data-driven approach based on graph theory assessment and functional connectivity density (FCD), which can be interpreted as short-range (intraregional) or long-range (interregional) mapping.

Results

Compared with healthy controls with good sleep, CID patients showed significantly dec

SUBMITTER: Zhou F 

PROVIDER: S-EPMC7667361 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature