Construction of relapse-related lncRNA-mediated ceRNA networks in Hodgkin lymphoma.

ABSTRACT:

Introduction

Hodgkin lymphoma (HL) is a type of lymphoma common throughout the western countries. However, the detailed mechanisms and special biomarkers of HL remain to be further investigated. Emerging studies have shown that long non-coding RNAs play a key role in human cancers.

Material and methods

In the present work, we constructed relapse-related lncRNA-mediated ceRNA networks in HL. Additionally, we constructed co-expression networks for these relapse-related lncRNAs. We also constructed a relapse-related lncRNA-miRNA-mRNA network to study the potential mechanism of these lncRNAs. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore functions of DEGs in Hodgkin lymphoma.

Results

A total o

SUBMITTER: Liang Y 

PROVIDER: S-EPMC7667426 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature