Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton.

ABSTRACT: Obstructive sleep-disordered breathing (SDB), which includes primary snoring through to obstructive sleep apnea syndrome (OSAS), may cause compromise of respiratory gas exchange during sleep, related to transient upper airway narrowing disrupting ventilation, and causing oxyhemoglobin desaturation and poor sleep quality. SDB is common in chronic disorders and has significant implications for health. With prevalence rates globally increasing, this condition is causing a substantial burden on health care costs. Certain populations, including people with sickle cell disease (SCD), exhibit a greater prevalence of OSAS. A review of the literature provides the available normal polysomnography and oximetry data for reference and documents the structural upper airway differences between those with

SUBMITTER: Brennan LC 

PROVIDER: S-EPMC7667585 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature