YTHDF1-enhanced iron metabolism depends on TFRC m⁶A methylation.

ABSTRACT: Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-methyladenosine (m⁶A) modification has expanded the realm of previously undiscovered post-transcriptional gene regulation mechanisms in eukaryotes. Many studies have demonstrated that m⁶A methylation represents a distinct layer of epigenetic deregulation in carcinogenesis and tumor proliferation. However, the status of m⁶A modification and iron metabolism in HPSCC remains unknown. Methods: Bioinformatics analysis, sample analysis, an

SUBMITTER: Ye J 

PROVIDER: S-EPMC7667694 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature