A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder.

ABSTRACT: Autism spectrum disorder is a neurodevelopmental disorder characterized by difficulties in social communication and interaction, as well as repetitive and characteristic patterns of behaviour. Although the pathogenesis of autism spectrum disorder is unknown, being overweight or obesity during infancy and low weight at birth are known as risks, suggesting a metabolic aspect. In this study, we investigated adipose tissue development as a pathophysiological factor of autism spectrum disorder by examining the serum levels of adipokines and other metabolic markers in autism spectrum disorder children (n = 123) and typically developing children (n = 92) at 4-12 years of age. Among multiple measures exhibiting age-dependent trajectories, the leptin levels displayed different traject

SUBMITTER: Maekawa M 

PROVIDER: S-EPMC7667725 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature