Fully Automated Radiosynthesis of [¹¹C]Guanidines for Cardiac PET Imaging.

ABSTRACT: Radiolabeled guanidines such as meta-iodobenzylguanidine (MIBG) find utility in nuclear medicine as both diagnostic imaging agents and radiotherapeutics and, over the years, numerous methods for incorporating radionuclides into guanidines have been developed. In connection with a project developing new positron emission tomography (PET) radiotracers for cardiac sympathetic nerve density, we had cause to prepare [¹¹C]3F-PHPOG. However, it quickly became apparent that radiolabeling of guanidine scaffolds with carbon-11 has remained challenging, and historical methods lack compatibility with modern automated radiochemistry synthesis platforms and current Good Manufacturing Practice (cGMP) requirements. To address this challenge, we report a new automated method for radiolabe

SUBMITTER: Zhao AY 

PROVIDER: S-EPMC7667854 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature