EGFR-mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions.

ABSTRACT: STING (STimulator of INterferon Genes) mediates protective cellular response to microbial infection and tissue damage, but its aberrant activation can lead to autoinflammatory diseases. Upon ligand stimulation, the endoplasmic reticulum (ER) protein STING translocates to endosomes for induction of interferon production, while an alternate trafficking route delivers it directly to the autophagosomes. Here, we report that phosphorylation of a specific tyrosine residue in STING by the epidermal growth factor receptor (EGFR) is required for directing STING to endosomes, where it interacts with its downstream effector IRF3. In the absence of EGFR-mediated phosphorylation, STING rapidly transits into autophagosomes, and IRF3 activation, interferon production, and antiviral activity are compromis

SUBMITTER: Wang C 

PROVIDER: S-EPMC7667877 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature