Interactions of ferritin with scavenger receptor class A members.

ABSTRACT: Scavenger receptors are a superfamily of membrane-bound receptors that recognize both self and nonself targets. Scavenger receptor class A (SR-A) has five known members (SCARA1 to -5 or SR-A1 to -A5), which are type II transmembrane proteins that form homotrimers on the cell surface. SR-A members recognize various ligands and are involved in multiple biological pathways. Among them, SCARA5 can function as a ferritin receptor; however, the interaction between SCARA5 and ferritin has not been fully characterized. Here, we determine the crystal structures of the C-terminal scavenger receptor cysteine-rich (SRCR) domain of both human and mouse SCARA5 at 1.7 and 2.5 Å resolution, respectively, revealing three Ca²⁺-binding sites on the surface. Using biochemical assays, we show that t

SUBMITTER: Yu B 

PROVIDER: S-EPMC7667961 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature