Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages.

ABSTRACT: Heavy metals released into the environment have a significant effect on respiratory health. Lung macrophages are important in mounting an inflammatory response to injury, but they are also involved in repair of injury. Macrophages develop mixed phenotypes in complex pathological conditions and polarize to a predominant phenotype depending on the duration and stage of injury and/or repair. Little is known about the reprogramming required for lung macrophages to switch between these divergent functions; therefore, understanding the mechanism(s) by which macrophages promote metabolic reprogramming to regulate lung injury is essential. Here, we show that lung macrophages polarize to a pro-inflammatory, classically activated phenotype after cadmium-mediated lung injury. Because metabolic adapta

SUBMITTER: Larson-Casey JL 

PROVIDER: S-EPMC7667973 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature