Long-term Persistence of Oral HPV Over 7 Years of Follow-up.

ABSTRACT:

Background

Human papillomavirus-related oropharyngeal cancer (HPV-OPC) incidence is increasing, but the natural history of the precursor-oral HPV-has not been well described.

Methods

This observational cohort study of people living with HIV and at-risk HIV uninfected people evaluated participants semiannually using 30-second oral rinse and gargle specimens over 7 years. Initially, 447 participants were followed for 4 years as part of the Persistent Oral Papillomavirus Study, and a subset of 128 who showed persistent infections at the last Persistent Oral Papillomavirus Study visit had an additional visit, as part of the Men and Women Understanding Throat HPV Study, on average 2.5 years later. Extracted DNA from oral rinse and gargle specimens was amplified using polymerase c

SUBMITTER: D'Souza G 

PROVIDER: S-EPMC7667996 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature