Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function.

ABSTRACT: Understanding the mechanisms of nanoparticle interaction with cell membranes is essential for designing materials for applications such as bioimaging and drug delivery, as well as for assessing engineered nanomaterial safety. Much attention has focused on nanoparticles that bind strongly to biological membranes or induce membrane damage, leading to adverse impacts on cells. More subtle effects on membrane function mediated via changes in biophysical properties of the phospholipid bilayer have received little study. Here, we combine electrophysiology measurements, infrared spectroscopy, and molecular dynamics simulations to obtain insight into a mode of nanoparticle-mediated modulation of membrane protein function that was previously only hinted at in prior work. Electrophysiology measureme

SUBMITTER: Foreman-Ortiz IU 

PROVIDER: S-EPMC7668003 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature