High-amplitude cofluctuations in cortical activity drive functional connectivity.

ABSTRACT: Resting-state functional connectivity is used throughout neuroscience to study brain organization and to generate biomarkers of development, disease, and cognition. The processes that give rise to correlated activity are, however, poorly understood. Here we decompose resting-state functional connectivity using a temporal unwrapping procedure to assess the contributions of moment-to-moment activity cofluctuations to the overall connectivity pattern. This approach temporally resolves functional connectivity at a timescale of single frames, which enables us to make direct comparisons of cofluctuations of network organization with fluctuations in the blood oxygen level-dependent (BOLD) time series. We show that surprisingly, only a small fraction of frames exhibiting the strongest cofluctuatio

SUBMITTER: Zamani Esfahlani F 

PROVIDER: S-EPMC7668041 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature