Baseline Metabolic Variables Do Not Predict Weight Regain in Premenopausal Women.

ABSTRACT:

Objective

The aim of this study was to investigate whether baseline (pre-weight loss) metabolic variables can predict weight regain.

Methods

About 117 women with overweight completed a weight loss program to achieve BMI < 25 kg/m² and were followed for 2 years. Resting metabolic rate, respiratory quotient, insulin sensitivity, and serum leptin concentration were measured pre-weight loss, while on energy balance, and as predictors of weight regain at 1 and 2 years. Rate and amount of weight loss also were examined as predictors, as these outcomes may reflect metabolic phenotype.

Results

Average weight loss was 12 (SD 2.5) kg, and regain was 48% (SD 35%) and 80% (SD 52%) at 1 and 2 years, respectively. In regression modeling, metabolic variables (both pre-wei

SUBMITTER: Martins C 

PROVIDER: S-EPMC7668116 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature