Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates.

ABSTRACT: The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using resting-state and reward-related functional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion showing the highest reward-related asymme

SUBMITTER: Lopez-Persem A 

PROVIDER: S-EPMC7668182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature