Brief Report: Chronic Placental Inflammation Among Women Living With HIV in Uganda.

ABSTRACT:

Background

HIV-exposed, uninfected (HEU) children have poorer early-life outcomes than HIV-unexposed children. The determinants of adverse health outcomes among HEU children are poorly understood but may result from chronic placental inflammation (CPI).

Setting and methods

We enrolled 176 pregnant women living with HIV (WLWH) taking antiretroviral therapy in southwestern Uganda and 176 HIV-uninfected women to compare CPI prevalence by maternal HIV serostatus. Placentas were evaluated histologically by an expert pathologist for presence of CPI, defined as chronic chorioamnionitis, plasma cell deciduitis, villitis of unknown etiology, or chronic histiocytic intervillositis. Placentas with CPI were additionally immunostained with CD3 (T cell), CD20 (B cell), and CD68 (macrophag

SUBMITTER: Bebell LM 

PROVIDER: S-EPMC7668230 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature