Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation.

ABSTRACT:

Background

Based on inhibition of viral replication and limited reports on clinical efficacy, hydroxychloroquine is being considered as prophylaxis and treatment of coronavirus disease-19 (COVID-19). Although hydroxychloroquine is generally considered safe during pregnancy based on studies in patients with systemic lupus erythematosus and other rheumatic conditions, there may still be reluctance to institute this antimalarial during pregnancy for the sole purpose of antiviral therapy.

Methods

To provide data regarding any potential fetal/neonatal cardiotoxicity, we leveraged a unique opportunity in which neonatal ECGs and hydroxychloroquine blood levels were available in a recently completed study evaluating the efficacy of hydroxychloroquine 400 mg daily to prevent the recu

SUBMITTER: Friedman DM 

PROVIDER: S-EPMC7668319 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature