Vascular and metabolic risk factor differences prior to dementia diagnosis: a multidatabase case-control study using European electronic health records.

ABSTRACT:

Objective

The objective of the study is to compare body mass index (BMI), systolic/diastolic blood pressure (SBP/DBP) and serum total cholesterol levels between dementia cases and controls at multiple time intervals prior to dementia onset, and to test time interval as a modifying factor for these associations.

Design

Case-control study.

Setting

Six European electronic health records databases.

Participants

291 780 cases at the date of first-recorded dementia diagnosis, compared with 29 170 549 controls randomly selected from the same databases, age matched and sex matched at this index date.

Exposure

The following measures were extracted whenever recorded within each dataset: BMI (kg/m²), SBP and DBP (mm Hg) and serum total cholesterol (mmol/

SUBMITTER: Perera G 

PROVIDER: S-EPMC7668358 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature