Dataset Information

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

ABSTRACT:

Background

Magnesium sulfate (MgSO4) is widely used in analgesia for different conditions. Recent randomized controlled trials (RCTs) have evaluated the effects of MgSO4 on renal colic; however, this new evidence has not been synthesized. Thus, we conducted a systematic review and meta-analysis to assess the efficacy and safety of MgSO4 in comparison with control for renal colic.

Methods

PubMed, EMBASE, and Scopus databases were searched from inception to February 2020. We included RCTs that evaluated MgSO4 vs control for patients with renal colic. Data were independently extracted by 2 reviewers and synthesized using a random-effects model.

Results

Four studies with a total of 373 patients were analyzed. Intravenous MgSO4 15 to 50 mg/kg did not significantly reduce renal colic pain severity at 15 minutes (mean difference [MD] = 0.35, 95% confidence interval [CI] -0.51 to 1.21; 2 RCTs), 30 minutes (MD = 0.19, 95% CI -0.74 to 1.13; 4 RCTs), and 60 minutes (MD = -0.28, 95% CI -0.72 to 0.16; 3 RCTs) in comparison with controls. In patients who failed to respond to initial analgesics, intravenous MgSO4 15 mg/kg or 2 ml of 50% solution provided similar pain relief to ketorolac or morphine at 30 minutes (P = .90) and 60 minutes (P = .57). No significant hemodynamic changes were observed with short-term use of MgSO4 in these studies.

Conclusion

MgSO4 provides no superior therapeutic benefits in comparison with control treatments. MgSO4 may be used as a rescue medication in patients not responding to initial analgesics. The short-term use of MgSO4 did not affect hemodynamic values.

SUBMITTER: Chen LF

PROVIDER: S-EPMC7668463 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

Chen Liang-Fu LF Yang Chih-Hao CH Lin Ting-Yi TY Pao Po-Jia PJ Chu Karen Chia-Wen KC Hsu Chin-Wang CW Bai Chyi-Huey CH Du Ming-Hai MH Hsu Yuan-Pin YP

Medicine 20201101 46

<h4>Background</h4>Magnesium sulfate (MgSO4) is widely used in analgesia for different conditions. Recent randomized controlled trials (RCTs) have evaluated the effects of MgSO4 on renal colic; however, this new evidence has not been synthesized. Thus, we conducted a systematic review and meta-analysis to assess the efficacy and safety of MgSO4 in comparison with control for renal colic.<h4>Methods</h4>PubMed, EMBASE, and Scopus databases were searched from inception to February 2020. We include ...[more]

PMID: 33181719

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Dataset Information

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

Background

Methods

Results

Conclusion

Publications

Effect of magnesium sulfate on renal colic pain: A PRISMA-compliant meta-analysis.

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