A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS.

ABSTRACT:

Objective

To evaluate progressive white matter (WM) degeneration in amyotrophic lateral sclerosis (ALS).

Methods

Sixty-six patients with ALS and 43 healthy controls were enrolled in a prospective, longitudinal, multicenter study in the Canadian ALS Neuroimaging Consortium (CALSNIC). Participants underwent a harmonized neuroimaging protocol across 4 centers that included diffusion tensor imaging (DTI) for assessment of WM integrity. Three visits were accompanied by clinical assessments of disability (ALS Functional Rating Scale-Revised [ALSFRS-R]) and upper motor neuron (UMN) function. Voxel-wise whole-brain and quantitative tract-wise DTI assessments were done at baseline and longitudinally. Correction for site variance incorporated data from healthy controls and from health

SUBMITTER: Kalra S 

PROVIDER: S-EPMC7668555 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature