Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity.

ABSTRACT:

Background

Monitoring and treating metastatic progression remains a formidable task due, in part, to an inability to monitor specific differential molecular adaptations that allow the cancer to thrive within different tissue types. Hence, to develop optimal treatment strategies for metastatic disease, an important consideration is the divergence of the metastatic cancer growing in visceral organs from the primary tumor. We had previously reported the establishment of isogenic human metastatic breast cancer cell lines that are representative of the common metastatic sites observed in breast cancer patients.

Methods

Here we have used proteomic, RNAseq, and metabolomic analyses of these isogenic cell lines to systematically identify differences and commonalities in pathway netw

SUBMITTER: Winnard PT 

PROVIDER: S-EPMC7668614 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature