A phenome-wide association study of ABO blood groups.

ABSTRACT:

Background

ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood. To gain sex-specific additional insight about potential mechanisms driving these common conditions for future interventions, we characterized associations of ABO blood group antigen across the phenotype sex-specifically.

Methods

We performed a phenome-wide association study (PheWAS) assessing the association of tag single nucleotide polymorphisms (SNPs) for ABO blood group antigens (O, B, A₁, and A₂) with 3873 phenotypes.

Results

The tag SNP for the O antigen was inversely associated with diseases of the circulatory system (particularly deep vein thrombosis (DVT)), total cholesterol, low-d

SUBMITTER: Li S 

PROVIDER: S-EPMC7669452 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature