Decreased serial scores of severe organ failure assessments are associated with survival in mechanically ventilated patients; the prospective Maastricht Intensive Care COVID cohort.

ABSTRACT:

Background

The majority of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are admitted to the Intensive Care Unit (ICU) for mechanical ventilation. The role of multi-organ failure during ICU admission as driver for outcome remains to be investigated yet.

Design and setting

Prospective cohort of mechanically ventilated critically ill with SARS-CoV-2 infection.

Participants and methods

94 participants of the MaastrICCht cohort (21% women) had a median length of stay of 16 days (maximum of 77). After division into survivors (n = 59) and non-survivors (n = 35), we analysed 1555 serial SOFA scores using linear mixed-effects models.

Results

Survivors improved one SOFA score point more per 5 days (95% CI: 4-8) than non-survivors.

SUBMITTER: Bels JLM 

PROVIDER: S-EPMC7669472 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature