Rapid Identification of KL49 Acinetobacter baumannii Associated with Clinical Mortality.

ABSTRACT:

Objective

We aimed to establish a tool for rapid identification of KL49 Acinetobacter baumannii.

Methods

Based on the capsular polysaccharide (CPS) synthesis genes database, we investigated the distribution of K locus type 49 (KL49) genes in other KL types and established a rapid identification method for KL49. We collected 61 clinical carbapenem-resistant A. baumannii (CRAB) strains, identified KL49 by gtr100 detection, and used whole genome sequencing (WGS) for verification. A mouse pneumonia model was used to confirm the hypervirulence phenotype. We tested the presence of gtr100 gene in 165 CRAB strains from three provinces in China and evaluated the correlation of gtr100 carrying CRAB infection with mortality.

Results

The gtr1

SUBMITTER: Deng Q 

PROVIDER: S-EPMC7669520 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature