Functional Genetic Variation in the 3'-UTRNTRK2 is Associated with Risk of Ischemic Stroke.

ABSTRACT:

Background

Stroke is a leading cause of death and disability worldwide. It remains difficult to treat brain injury and improve functional rehabilitation after cerebral ischemia. Brain-derived neurotrophic factor (BDNF) is involved in ischemic stroke (IS) through interactions in the CREB1-BDNF-NTRk2 pathway. In this study, we aimed to determine the association of NTRK2 gene polymorphisms and the effects of intergenetic interactions in the Chinese population.

Materials and methods

A total of 400 patients diagnosed with IS and 400 healthy controls were enrolled for genotyping. Detailed sequence-based analysis was predicted through bioinformatical investigation. Polymorphisms associated with miRNA were analyzed by a dual-luciferase reporter assay system.

SUBMITTER: Shi J 

PROVIDER: S-EPMC7669521 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature