Analyses of Potential Driver and Passenger Bacteria in Human Colorectal Cancer.

ABSTRACT:

Introduction

Besides genetic and epigenetic alterations that lead to carcinogenesis and development of colorectal cancer (CRC), intestinal microbiomes are recently recognized to play a critical role in CRC progression. The abundant species associated with human CRC have been proposed for their roles in promoting tumorigenesis. However, a recent "driver-passenger" model suggests that these CRC-associated species with high relative abundances may be passenger bacteria that take advantage of the tumor environment instead of initiating CRC, whereas the driver species that initiate CRC have been replaced by passenger bacteria due to the alteration of the intestinal niche.

Methods

Here, to reveal potential driver and passenger bacteria during CRC progression, we compare the gut mu

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7669530 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature