Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.

ABSTRACT: Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipulation of dietary fatty acids decreased headache frequency, severity, and pain medication use. Pain reduction was associated with alterations in oxylipins derived from n-3 and n-6 fatty acids, suggesting that oxylipins could potentially mediate clinical pain reduction. The objective of this study was to investigate whether circulating oxylipins measured in the acute setting after TBI could serve as prognostic biomarkers for developing chronic PTH. Participants enrolled in the

SUBMITTER: Domenichiello AF 

PROVIDER: S-EPMC7669546 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature