Circulating microbial small RNAs are altered in patients with rheumatoid arthritis.

ABSTRACT:

Objectives

To determine if plasma microbial small RNAs (sRNAs) are altered in patients with rheumatoid arthritis (RA) compared with control subjects, associated with RA disease-related features, and altered by disease-modifying antirheumatic drugs (DMARDs).

Methods

sRNA sequencing was performed on plasma from 165 patients with RA and 90 matched controls and a separate cohort of 70 patients with RA before and after starting a DMARD. Genome alignments for RA-associated bacteria, representative bacterial and fungal human microbiome genomes and environmental bacteria were performed. Microbial genome counts and individual sRNAs were compared across groups and correlated with disease features. False discovery rate was set at 0.05.

Results

Genome counts of Lactobacillus s

SUBMITTER: Ormseth MJ 

PROVIDER: S-EPMC7669585 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature