Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.

ABSTRACT: Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary system to connect molecular mechanisms to biological outcomes due to its strong genetic links to different specific human diseases. Recent advances in structural and computational biology provide a unique opportunity to re-examine biologically relevant molecular structures and develop possible mechanistic insights for the large dynamic TFIIH complex. TFIIH presents many puzzles involving how its two SF2 helicase family enzymes, XPB and XPD, function in transcription initiation and repair: how do they initiate transcription, detect and verify DNA damage, select the damaged strand for incision, coordinate repair with transcription and cell cycle through Cdk-activating-kinase (CAK) signaling, and re

SUBMITTER: Tsutakawa SE 

PROVIDER: S-EPMC7669588 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature