A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia.

ABSTRACT: Alterations in cellular energy metabolism have been implicated in chronic pain, suggesting a role for mitochondrial DNA. Previous studies reported associations of a limited number of mitochondrial DNA polymorphisms with specific pain conditions. In this study, we examined the full mitochondrial genomes of people with a variety of chronic pain conditions. A discovery cohort consisting of 609 participants either with or without a complex persistent pain conditions (CPPCs) was examined. Mitochondrial DNA was subjected to deep sequencing for identification of rare mutations, common variants, haplogroups, and heteroplasmy associated with 5 CPPCs: episodic migraine, irritable bowel syndrome, fibromyalgia, vulvar vestibulitis, or temporomandibular disorders. The strongest association found was th

SUBMITTER: van Tilburg MAL 

PROVIDER: S-EPMC7669626 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature