Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury.

ABSTRACT: Multidomain peptide (MDP) hydrogels are a class of self-assembling materials that have been shown to elicit beneficial responses for soft tissue regeneration. However, their capacity to promote nervous system regeneration remains unknown. The peripheral nervous system (PNS) substantially recovers after injury, partly due to the abundance of extracellular matrix (ECM) components in its basal lamina. However, severe peripheral nerve injuries that significantly damage the ECM continue to be a major clinical challenge as they occur at a high rate and can be extremely detrimental to patients' quality of life. In this study, a panel of eight MDPs were designed to contain various motifs mimicking extracellular matrix components and growth factors and successfully self-assembled into injectable, n

SUBMITTER: Lopez-Silva TL 

PROVIDER: S-EPMC7669633 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature