Delineation of clinical and biological factors associated with cutaneous squamous cell carcinoma among patients with chronic lymphocytic leukemia.

ABSTRACT:

Background

The incidence of cutaneous squamous cell carcinoma (SCC) in patients with chronic lymphocytic leukemia (CLL) is significantly higher compared with age- and sex-matched controls.

Objective

To evaluate the association of factors associated with SCC risk.

Methods

Clinical CLL and SCC data were obtained from Mayo Clinic CLL Resource and self-reported questionnaires among patients with newly diagnosed CLL. We computed the CLL International Prognostic Index (CLL-IPI) from CLL prognostic factors, and a polygenic risk score from SCC susceptibility variants. We used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Among 1269 patients with CLL, the median follow-up was 7 years, and SCC subsequently developed in 124 pat

SUBMITTER: Kleinstern G 

PROVIDER: S-EPMC7669637 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature