Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models.

ABSTRACT: Lipids play an essential role in development, homeostatic functions, immune signaling, reproduction, and growth. Although it is evident that changes in lipid biosynthesis and metabolism can affect organismal physiology, few studies have determined how environmental stressors affect lipid pathways, let alone alter global lipid profiles in fish. This is a significant research gap, as a number of environmental contaminants interact with lipid signaling and metabolic pathways. In this review, we highlight the utility of lipidomics as a tool in environmental toxicology, discussing the current state of knowledge regarding chemical-lipidomic perturbations. As with most oviparous animals, the processing and storage of lipids during oocyte development is also particularly important for embryogenesi

SUBMITTER: Dreier DA 

PROVIDER: S-EPMC7669741 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature