SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy.

ABSTRACT:

Objective

Brain calcifications are associated with several neurodegenerative diseases. Here, we describe the occurrence of intracranial calcifications as a new phenotype in transgenic P301L mice overexpressing four repeat tau, a model of human tauopathy.

Materials and methods

Thirty-six P301L mice (Thy1.2) and ten age-matched non-transgenic littermates of different ages were assessed. Gradient echo data were acquired in vivo and ex vivo at 7 T and 9.4 T for susceptibility-weighted imaging (SWI) and phase imaging. In addition, ex vivo micro-computed tomography (μCT) was performed. Histochemistry and immunohistochemistry were used to investigate the nature of the imaging lesions.

Results

SW images revealed regional hypointensities in the hippocampus, cortex, caudate nuc

SUBMITTER: Ni R 

PROVIDER: S-EPMC7669813 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature