Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
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ABSTRACT:
SUBMITTER: Rodriguez-Fdez S
PROVIDER: S-EPMC7669868 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Rodríguez-Fdez Sonia S Lorenzo-Martín L Francisco LF Fernández-Pisonero Isabel I Porteiro Begoña B Veyrat-Durebex Christelle C Beiroa Daniel D Al-Massadi Omar O Abad Antonio A Diéguez Carlos C Coppari Roberto R Nogueiras Rubén R Bustelo Xosé R XR
Nature communications 20201116 1
Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates the signaling output of the IGF1- and insulin-stimulated phosphatidylinositol 3-kinase pathway in that tissue. Consistent with this, mice bearing a Vav2 protein with decreased catalytic activity exhibit reduced muscle mass, lack of proper insulin responsiveness and, at much later times, a ...[more]
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