PET/CT imaging for tumour response assessment to immunotherapy: current status and future directions.

ABSTRACT: Recent immunotherapeutic approaches have evolved as powerful treatment options with high anti-tumour responses involving the patient's own immune system. Passive immunotherapy applies agents that enhance existing anti-tumour responses, such as antibodies against immune checkpoints. Active immunotherapy uses agents that direct the immune system to attack tumour cells by targeting tumour antigens. Active cellular-based therapies are on the rise, most notably chimeric antigen receptor T cell therapy, which redirects patient-derived T cells against tumour antigens. Approved treatments are available for a variety of solid malignancies including melanoma, lung cancer and haematologic diseases. These novel immune-related therapeutic approaches can be accompanied by new patterns of response and pr

SUBMITTER: Unterrainer M 

PROVIDER: S-EPMC7669926 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature