Fully automated radiosynthesis of [¹⁸F]LBT999 on TRACERlab FX_FN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain.

ABSTRACT:

Background

Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([¹⁸F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the dopamine transporter by Positron Emission Tomography (PET). [¹⁸F]LBT999 was produced on a TRACERlab FXFN for the Phase I study but for Phase III and a potent industrial production transfer, production was also implemented on an AllinOne (AIO) system requiring a single use cassette. Both production methods are reported herein.

Results

Automation of [¹⁸F]LBT999 radiosynthesis on FXFN was carried out in 35% yield (decay-corrected) in 65 min (n = 16), with a radiochemical purity higher than 99% and a molar activity of 158 GBq/μ

SUBMITTER: Vala C 

PROVIDER: S-EPMC7669936 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature