Dissecting the eQTL Micro-Architecture in Caenorhabditis elegans.

ABSTRACT: The study of expression quantitative trait loci (eQTL) using natural variation in inbred populations has yielded detailed information about the transcriptional regulation of complex traits. Studies on eQTL using recombinant inbred lines (RILs) led to insights on cis and trans regulatory loci of transcript abundance. However, determining the underlying causal polymorphic genes or variants is difficult, but ultimately essential for the understanding of regulatory networks of complex traits. This requires insight into whether associated loci are single eQTL or a combination of closely linked eQTL, and how this QTL micro-architecture depends on the environment. We addressed these questions by testing for independent replication of previously mapped eQTL in Caenorhabditis elega

SUBMITTER: Sterken MG 

PROVIDER: S-EPMC7670075 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature