Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC.

ABSTRACT:

Background

Bone metastasis can induce multiple types of bone diseases which reduce the non-small-cell lung cancer (NSCLC) patient's quality-of-life. Due to the difficulty of finding bone metastases and lack of effective early diagnosis, it is easy to miss the best treatment. Therefore, the study of serum tumor biomarkers is of great significance in the diagnosis of NSCLC bone metastasis.

Methods

The qRT-PCR assay was performed to assess has_circ_0060937 expression in 100 NSCLC patients. Furthermore, the small interfering RNAs si-has_circ_0060937 or si-NC were transfected into NSCLC bone metastasis cells. CCK8 assay was exercised to detect cell proliferation, and cell invasion assays were used to detect cell invasion in NSCLC bone metastasis cells.

Results

In this stud

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7670089 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature