CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis.

ABSTRACT:

Background

CXCL13 is a B and T lymphocyte chemokine that mediates neuroinflammation through its receptor CXCR5. This chemokine is highly expressed by motoneurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) SOD1G93A (mSOD1) mice during the disease, particularly in fast-progressing mice. Accordingly, in this study, we investigated the role of this chemokine in ALS.

Methods

We used in vitro and in vivo experimental paradigms derived from ALS mice and patients to investigate the expression level and distribution of CXCL13/CXCR5 axis and its role in MN death and disease progression. Moreover, we compared the levels of CXCL13 in the CSF and serum of ALS patients and controls.

Findings

CXCL13 and CXCR5 are overexpressed in the spinal MNs and peripheral axons in mSOD1 mice.

SUBMITTER: Trolese MC 

PROVIDER: S-EPMC7670099 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature