Association between the metabolome and bone mineral density in a Chinese population.

ABSTRACT:

Background

Osteoporosis is a common metabolic bone disease, which always leads to osteoporotic fractures. Biomarkers of bone mineral density (BMD) are helpful for prevention and early diagnosis of osteoporosis. This study aims to identify metabolomic biomarkers of low BMD.

Methods

We included 701 participants who had BMD measures by dual-energy X-ray absorptiometry scans and donated fasting plasma samples from three clinical centres as a discovery set and another 278 participants from the fourth centre as an independent replication set. We used a liquid chromatography-mass spectrometry-based metabolomics approach to profile the global metabolites of fasting plasma.

Findings

Among the 265 named metabolites identified in our study, six were associated with low BMD (FDR-

SUBMITTER: Mei Z 

PROVIDER: S-EPMC7670189 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature