Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review.

ABSTRACT: Inter-individual differences in defensive responding are widely established but their morphological correlates in humans have not been investigated exhaustively. Previous studies reported associations with cortical thickness of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygdala volume in fear conditioning studies. However, these associations are partly inconsistent and often derived from small samples. The current study aimed to replicate previously reported associations between physiological and subjective measures of fear acquisition and extinction and brain morphology. Structural magnetic resonance imaging was performed on 107 healthy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction while skin

SUBMITTER: Ehlers MR 

PROVIDER: S-EPMC7670460 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature