Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner.

ABSTRACT: Propionate has been reported to exert antidepressant effects, but high-dose propionate may induce autism-like symptoms in experimental animals through induction of dysbiosis of neurotransmitters. The bi-directional effects of propionate seem to be dose-dependent. However, due to the pathological discrepancies between depression and autism, conclusions drawn from autism may not be simply transferable to depression. The effect and underlying action mechanisms of high-dose propionate on depression remains undetermined. To investigate the effects of propionate on depression, propionate dose gradients were intravenously administrated to rats exposed to chronic unpredictable mild stress (CUMS) for 1 week. Results of these behavioral tests demonstrate that low-dose propionate (2 mg/kg body weight

SUBMITTER: Hao C 

PROVIDER: S-EPMC7670463 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature