Immune-related miRNA signature identifies prognosis and immune landscape in head and neck squamous cell carcinomas.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is recognised as an immune active cancer, but little is known about the role of microRNAs (miRNAs) in it. In the present study, we aim to determine a prognostic and immune-related miRNAs signature (IRMS) in HNSCC.

Methods

Spearman correlation analysis was used to screen out prognostic immune-related miRNAs based on single-sample gene set enrichment analysis (ssGSEA). Least absolute shrinkage and selection operator (LASSO) Cox regression model was used to establish IRMS in HNSCC. Then, the influence of the IRMS on HNSCC was comprehensively analysed.

Results

We obtained 11 prognostic immune-related miRNAs based on ssGSEA. Then an IRMS integrated with six miRNAs was established through LASSO Cox regression analysis

SUBMITTER: Ma B 

PROVIDER: S-EPMC7670576 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature