Breast cancer risk factors and their effects on survival: a Mendelian randomisation study.

ABSTRACT:

Background

Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mendelian randomisation (MR) approach, we aimed to examine the potential causal association between breast cancer-specific survival and nine established risk factors for breast cancer: alcohol consumption, body mass index, height, physical activity, mammographic density, age at menarche or menopause, smoking, and type 2 diabetes mellitus (T2DM).

Methods

We conducted a two-sample MR analysis on data from the Breast Cancer Association Consortium (BCAC) and risk factor summary estimates from the GWAS Catalog. The BCAC data inclu

SUBMITTER: Escala-Garcia M 

PROVIDER: S-EPMC7670589 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature