DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial.

ABSTRACT:

Background

One of the major challenges in obesity treatment is to explain the high variability in the individual's response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DNA methylation changes reflect individual responsiveness to lifestyle intervention and may serve as epigenetic predictors for a successful weight-loss.

Methods

We conducted an explorative genome-wide DNA methylation analysis in blood samples from 120 subjects (90% men, mean ± SD age = 49 ± 9 years, body mass-index (BMI) = 30.2 ± 3.3 kg/m²) from the 18-month CENTRAL randomized controlled trial who underwent either Mediterranean/low-carbohydrate or low-fat diet with or without physical activity.

Results

Analyses comparing mal

SUBMITTER: Keller M 

PROVIDER: S-EPMC7670623 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature