The study of neuroprotective effects and underlying mechanism of Naoshuantong capsule on ischemia stroke mice.

ABSTRACT:

Background

Naoshuantong capsule (NSTC) is an oral Chinese medicine formula composed of Typhae Pollen, Radix Paeoniae Rubra, Curcumae Radix, Gastrodiae Rhizoma and Radix Rhapontici. It has been widely used at the acute and recovery stage of ischemic stroke since 2001. Comparing with its wide clinical application, there are only few studies emphasize on investigating its pharmacological effects.

Methods

To more generally elucidate the underlying mechanisms in this study, we identified active ingredients in NSTC by a network pharmacology approach based on transcriptomics analysis and pharmacological experiments. Modified neurological severity scores and morphometric analysis using Nissl staining were employed to evaluate the neuroprotective effects of NSTC on ischemia stroke in

SUBMITTER: Luo L 

PROVIDER: S-EPMC7670690 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature